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Background/objective: intravenous methylprednisolone (ivmp) is previously given to secondary progressive multiple sclerosis (spms) patients. This study was designed to examine the possible role of high-dose intravenous methylprednisolone (ivmp) in the development of venous thrombosis (vt). A common dose schedule for the intravenous route is methylprednisolone 1 g each day for 3 to 5 days, and this is often followed by an oral prednisone taper. The most commonly used dosage regimen is 500–1,000mg of ivmp daily for three to five days, with or without a subsequent tapering dose of oral. We report a case of high-dose prednisolone-induced acute hepatitis in a. 48-year-old woman suffering from multiple sclerosis that recurred after repeated Treatments for ms attacks. Corticosteroids, such as oral prednisone and intravenous methylprednisolone, are prescribed to reduce nerve. Getting treatment can make you less likely to have relapses. 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